Clinical & Experimental Cardiology
Open Access

Abstract

Therapeutic Potential of Pera Orange and Moro Orange in Cardiac Remodeling by Cardiovascular Diseases: A Metabolomics Approach

Anderson S.S. Fujimori, Bertha Furlan Polegato, Priscila Portugal dos Santos*

Cardiovascular diseases is a leading cause of death worldwide and the process of cardiac remodeling lies at the core of most of these diseases. The sustained cardiac remodeling almost unavoidably ends in progressive muscle dysfunction, heart failure and ultimately death. Therefore, in order to attenuate cardiac remodeling and reduce mortality, different therapies have been used, but it is important to identify adjuvant factors that can help to modulate this process. One of these factors is inclusion of affordable foods in the diet having potential cardio protective properties. Study carried out by Fujimori, et al. showed that ingestion of pera and moro orange juice induces changes in plasma metabolites related to the regulation of extracellular matrix, inflammation, oxidative stress, and membrane integrity in healthy rats. Additionally, the review of the metabolic pathways related to these compounds showed that they are mainly associated with phospholipid metabolism, cannabinoid system and microbiota metabolism. Therefore, ingestion of pera orange and moro orange juice induces changes in plasma metabolites that may be important for modulating cardiac remodeling induced by cardiovascular diseases.

Published Date: 2025-04-25; Received Date: 2023-09-14