Pancreatic Disorders & Therapy
Open Access
ISSN: 2165-7092
ISSN: 2165-7092
Saksham Gupta*, Andrea Cross, David Burnett and Steve Smith
Introduction: Delayed Gastric Emptying (DGE) following pancreaticoduodenectomy occurs in approximately 30% of patients, leading to longer hospital stays. Braun Enteroenterostomy (BE) is a surgical technique employed to reduce the incidence of DGE, however the current literature base is inconclusive with underpowered studies.
Methods: A systematic database search (Pubmed, Medline, Embase, Scopus and the cochrane central register of controlled trials) for randomised studies was performed using pre-specified search terms reviewing the utility of a BE with pancreaticoduodenectomy. This review was performed according to PRISMA guidelines. Included studies were assessed for bias using risk of bias 2 tool. Revman ver5.4 was used for data analysis; fixed-effects Mantel-Haenszel test was performed for dichotomous outcomes and continuous data was analysed using the Inverse Variance method.
Results: Five studies were considered suitable for inclusion for meta-analysis, resulting in a total of 407 participants, of which 178 received a BE. BE was associated with a reduction in DGE (odds ratio 0.51; 95% confidence interval 0.30-0.87, p=0.01), however no difference was seen with grade B/C DGE, post-operative pancreatic fistula and length of stay. Three studies were considered high risk of bias, and there was variability in surgical technique.
Conclusion: Meta-analysis suggests inclusion of BE may lead to a reduction in the incidence of DGE, however methodological weaknesses in available literature necessitates the need for further robust studies.
Published Date: 2025-12-08; Received Date: 2025-11-08