Reproductive System & Sexual Disorders: Current Research
Open Access

Abstract

The Role of Multi-Parametric MRI and Fusion Biopsy for the Diagnosis of Prostate Cancer – A Systematic Review

Sarkar D

Introduction: The use of multiparametric MRI (MpMRI) guided fusion biopsy is becoming an increasingly popular investigation in an aid to increase diagnostic yield in those suspected of having prostate cancer (PCa). Before adopting this technology, it is necessary to confirm the accuracy, so that PCa can be reliably diagnosed with characterization.

Materials and Methods: This review analyses the evidences, which varied from well-designed randomized controlled trials to case series to detect the accuracy of MpMRI comparing with biopsy/histology.

Results: MpMRI incorporating T2 and diffusion weighted imaging only detects tumor in around 92% cases. When dynamic contrast enhancement is added, cancer diagnosis is significantly improved. Fusion biopsy increases the detection of high-risk PCa by 32% over conventional biopsy alone.

Conclusion: This review also revealed that fusion biopsy did not increase cancer detection rate but combined biopsy (systematic and fusion) provide the highest detection rate for the diagnosis of PCa.