Journal of Genetic Syndromes & Gene Therapy
Open Access

Abstract

The Ratio of Glycated Albumin to HbA1c is Correlated with Diabetes Duration According to Decreases in Insulin Secretion in Patients with Autoimmune Type 1 Diabetes and Type 2 Diabetes

Hirata T, Saisho Y, Morimoto J, Kasayama S, Koga M and Maruyama T

Glycated albumin (GA) is a marker of glycemic control that reflects postprandial plasma glucose levels and glycemic excursions better than HbA1c. However, no reports have examined correlations between diabetes duration and the ratio of glycated albumin to HbA1c (GA/HbA1c ratio) in patients with autoimmune type 1 diabetes (T1AD) or type 2 diabetes (T2D). We conducted a cross-sectional study involving 219 patients with T1AD and 141 patients with T2D. We evaluated correlations between diabetes duration, the GA/HbA1c ratio and fasting serum C-peptide immunoreactivity (CPR), index of insulin secretion capacity. The GA/HbA1c ratio was significantly correlated with diabetes duration in both T1AD and T2D patients (T1AD; R=0.139, p<0.001, T2D; R=0.340, p<0.001). Fasting serum CPR was inversely correlated with diabetes duration (T1AD: R=-0.280, p<0.001; T2D: R=-0.349, p<0.001) as well as the GA/HbA1c ratio (T1AD: R=-0.240, p<0.001; T2D: R=-0.378, p<0.001) in both T1AD and T2D patients. We firstly reported that the GA/HbA1c ratio was positively correlated with diabetes duration in both T1AD and T2D patients. Insulin secretion capacity might influence this relationship.