Chemotherapy-Induced Peripheral Neuropathy is a common, dose-limiting effect of chemotherapy treatment. Pharmacological therapies are largely uneffective, making the investigation of other interventions warranted. Homebased exercise programs have produced promising improvements in quality of life and pain symptoms, yet compliance to programs is low. Thus, the purpose of this investigation was to examine the outcomes of a structured, supervised exercise program in reducing symptoms of CIPN and improving physical fitness and overall QOL. A total of 38 individuals actively in chemotherapy treatment participated in this investigation. The McGill QOL and Leeds Assessment of Neuropathic Symptoms and Signs questionnaires, followed by a comprehensive fitness evaluation was administered both before and after the 12-week supervised exercise program. Results revealed that 12-weeks of supervised exercise training helped attenuate symptoms of CIPN. Overall QOL was significantly improved, and troublesome symptoms related to CIPN significantly decreased (p<0.05). Thus, we assert that exercise is an effective tool in managing symptoms of CIPN.