Journal of Antivirals & Antiretrovirals

Journal of Antivirals & Antiretrovirals
Open Access

ISSN: 1948-5964


Short Term Survival after Anti-Retroviral Therapy Initiation among Aids Patients from South India

Sreenivasan Srirangaraj and Dasegowda Venkatesha

Background: The one-year survival rate of adults with the Acquired Immunodeficiency Syndrome (AIDS) after Anti Retroviral Therapy (ART) initiation and data on the efficacy of generic ART has not been well documented in India. The other objective was to see if opportunistic Infections were a significant risk factor for mortality. Methodology: Survival was studied in a prospective observational cohort study of 108 ART-naïve patients with AIDS in a South Indian state by Kaplan Meier estimates. Efficacy of different generic ART regimens was evaluated by Cox-regression analysis and multiple logistic regression analysis was performed to assess the role of opportunistic infections in mortality.
Results: The overall survival rate was 94.25% at 6 months and 88.46% at one year after ART initiation among persons who initiated therapy with CD4 counts < 200 cells/ There was no difference in survival between those on Efavirenz-based or nevirapine-based regimens. The mortality rate at the end of one year was 9% (nine deaths), out of which four deaths occurred within the first 90 days of ART initiation. Pulmonary Tuberculosis was a significant risk factor for mortality (OR = 4.768, p ≤ 0.05).
Conclusion: Generic ART is beneficial in a majority of AIDS patients in resource-limited settings. Pulmonary Tuberculosis is an important risk factor for mortality in AIDS patients on ART.