Objective: Most research regarding the effectiveness of brain tumor treatments measure survival time, recurrence rate, and extent of surgical resection. Objective measurements of functional abilities and self-perceived quality of life (QoL) are important aspects of treatment response, yet these are not commonly assessed. This study was designed to determine the relationship between balance and mobility status and self-perceived QoL for patients before and after surgical excision of primary brain tumors. Methods: Nine adults who underwent surgical excision of presumed primary brain tumor were assessed prior to, immediately following, and 3 months post-surgery utilizing the Timed Up-and-Go (TUG), Tinetti Performance- Oriented Mobility Assessment (Tinetti) and Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36). ANOVA with repeated measures over time was performed on the data across the three time points. Outcome measures were correlated using Spearman’s correlations. Statistical significance for all tests was accepted at p < 0.05. Results: Balance, mobility and QoL measures changed significantly from pre-surgery to immediately postsurgery and from immediately post-surgery to 3 months later. However, neither QoL nor balance or mobility demonstrated significant change from pre-surgery to 3 months post-surgery. These results reflect clinically-noted changes in physical abilities the 3 time points. All measures significantly correlated at the two post-surgery measurements, indicating a close link between balance and mobility and QoL. Conclusion: The TUG and Tinetti can be used in brain tumor patients to quantify clinical changes in balance and mobility. These changes correlate with QoL over time.