Journal of Thyroid Disorders & Therapy

Journal of Thyroid Disorders & Therapy
Open Access

ISSN: 2167-7948

+1 504 6082390


Refractory Graves’ disease With Ophthalmopathy in a 19-year Old Girl Managed Endoscopically: A Case Report

Gyan Chand, Nneka A Sunday-Nweke, Mallika Dhanda

Graves’ disease is an autoimmune disease of the thyroid gland which results from production of thyroid stimulating
immunoglobulins-TSI. These thyroid stimulating immunoglobulins bind to the thyroid stimulating hormone-TSH.
This leads to overproduction of thyroid hormones, necessitating excessive functions of these hormones in the body.
The commonest presentation is features of hyperthyroidism, occasionally with extra thyroidal features. Graves’ disease
is rare in children and adolescents, greater numbers are seen in adults, between fifth and sixth decades of life. We
report a case of 19-year-old girl who presented with anterior neck swelling of two years, associated with features of
hyperthyroidism and ophthalmopathy which were present at onset. Prior to presentation had received anti thyroid
treatments with drugs and radioiodine ablation one year ago and refractory to above treatment. Investigations showed
raised thyroxine, tri-iodothyronine, reduced thyroid stimulating hormone and markedly raised thyroid antibody.
Thyroid ultrasound showed enlargement of both lobes and isthmus with lobulated outlines, echotexture and
heterogenous fibrous bands. She was treated by endoscopic total thyroidectomy (Bilateral axillary and breast
approach) without postoperative complication and had since remained euthyroid with good cosmetic outcome. She is
currently on outpatient follow up.
Graves’ disease in teen age with ophtalmopathy is rare, and refractory with medical and RAI therapy. This can be well
managed endoscopically in expert hands.

Published Date: 2020-02-29; Received Date: 2020-01-31