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Despite the growth in the literature on the merits of treatment, opinion remains divided about the lack of relevant research on psychological intervention for sexually active minors. This study reports a systematic review of psychological intervention for sexually active among minors. One of the major psychological interventions is psychotherapy. Psychological intervention is a holistic and integrative intervention. Psychological intervention approach designed to maintain well-being and quality of life for sexually active minors. A systematic review was undertaken to investigate the effectiveness of psychological intervention for sexually active minors. Electronic online database searches were carried out to screen the publications between years 1990 to 2017. All searches revealed five publications related to psychological intervention used and the implications of these findings on the subsequent of intervention are discussed.