Biochemistry & Pharmacology: Open Access
Open Access

Abstract

Potential Oral Protective Effects of SNEDDS of Diclofenac Sodium on Experimental Gastric Ulcers in Rats

Gannu Praveen Kumar

The Self Nano Emulsifying Drug Delivery Systems (SNEDDS) have gained considerable interest over the past decade for their use in various applications. They have been shown to increase bioavailability and decrease side effects of highly toxic drugs. Non-Steroidal Anti-inflammatory Drugs (NSAIDS) such as Diclofenac Sodium (DFS) lead to major side effect gastric toxicity. The aim of this study was to formulate, characterize and evaluate DFS entrapped SNEDDS. SNEDDS were prepared by emulsion diffusion evaporation technique. DFS formulated SNEDDS showed the least size of 101 ± 3.5 nm, zeta potential of -18.5 ± 1.6 mv and entrapment efficiency of 90.6 ± 2.1 in FESIF respectively. The initial drug release was rapid in FASIF followed by phosphate buffer and the total drug release was high i.e; 74.18% in FASIF followed by phosphate buffer i.e; 70.14%. The drug released for 3-4 hrs approximately in all the media for 50% of release to occur except in SGF and FASGF in which the total percent release itself was 50% till 30 h. A significant reduction in toxicity of DFS was observed for SNEDDS in gastric mucosa when compared to free DFS with a 10 fold decrease in ulcer index of DFS in acute study and a 6.5 fold decrease in ulcer index of DFS in chronic study.