Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access

Abstract

Potential Benefit Of Mild Stimulation Regimen On Embryo Quality In IVF-ICSI Cycles

Jonathan Cohen, Raimond Nicolas, Christophe Sifer, Perrine Massart, Christophe Poncelet, Isabelle Cedrin-Durnerin and Jean-noël Hugues

Purpose: To assess the potential benefit of mild stimulation regimen on embryo quality in a specific subgroup of women who had previously experienced poor embryo quality after conventional regimen.

Methods: In this study performed in a single University Hospital, patients with at least 2 consecutive In Vitro Fertilisation (IVF) or Intra Cytoplasmic Sperm Injection (ICSI) attempts leading to poor embryo quality following conventional regimens were enrolled. The main purpose was to compare the absolute and relative number of good and top quality embryos following mild stimulation and conventional regimen.

Results: Mild stimulation regimen allowed the retrieval of a lower number of oocytes as compared to conventional protocol but the mean number and the percentage of good and top quality embryos were significantly increased in patients receiving the mild stimulation regimen

Conclusion: In a specific subgroup of women with poor embryo quality following conventional IVF-ICSI protocols, a mild stimulation regimen seems to improve embryo quality.