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We present a case of poroid hidradenoma on the right chest in a 62- year-old male with diabetes mellitus and chronic renal failure. Poroid hidradenoma is usually solitary and shows eccrine differentiation. There have been a small number of reports describing poroid hidradenoma, and the present case is a rare instance. Because the relations between clear cell neoplasms and diabetes mellitus are known, although it needs to further study of more cases of poroid hidradenoma with diabetes mellitus. Our hypotheses are that poroid hidradenoma may arise in diabetes mellitus patients with sufficient phosphorylase activity, and it may show solid and cystic components without a clear cell appearance.