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Physiological controls on cell adhesion mediated by E-cadherin have been frequently focused in the proliferation restraining. This can be given both by contact inhibition via the regulation of homotypic cadherin expression, by the control of adhesive strength, or even for the activation of proliferation mediated by growing factors. However, few studies have been conducted to evaluate the possible effects of hormones on the cell-cell adhesion mechanisms, during animal development and the maintenance of adult tissues and organs. Thus, the analysis of thyroid hormone influence on E-cadherin adhesive potential result highly challenging and promising field of research in cell biology.