Journal of Clinical Microbiology and Antimicrobials
Open Access
+44-77-2385-9429
+44-77-2385-9429
Hagar Hatem*, Rewan Abdelaziz
In the recent years have seen an increase in the prevalence of MDR bacteria, which pose major dangers to the general public's health. In fact, some strains are now practically immune to all of the widely used antibiotics. For example Methicillin-resistant Staphylococcus aureus (MRSA), which S. aureus has started to acquire antibiotic resistancet hat produced penicillinase, is a well-known example. A list of antibiotic-resistant infections for which new, potent drugs are urgently needed was released by the World Health Organisation (WHO). Additionally, the gram-negative pathogen Klebsiella pneumoniae is a clinically significant cause of sepsis, pneumonia, and other antibiotic-resistant infections in hospitals and the community. The development of Klebsiella pneumoniae strains that are resistant to carbapenem has been aided by the rising usage of antibiotics.
Bacteriophages are viruses that eradicate bacteria also known as "phages". Bacteriophages depend on host bacteria to grow since they lack a metabolism of their own. They are conceivably the most widespread and oldest known species on Earth, with some estimations placing their age at 3 billion years old. Phages are a typical component of the microflora of all fresh, unprocessed foods, and they play a critical role in maintaining microbial equilibrium in every ecosystem where bacteria thrive. Recently, interest in employing bacteriophages for various practical purposes has increased, with possibly the most effort going towards using them to increase food safety. Animal model development is still essential, though invertebrate and vertebrate models can be used to test the efficacy of therapies more swiftly and affordably than human trials while still being ethical. In the future, novel models might be taken into consideration, like the zebrafish, which is becoming more prominent for researching host-pathogen interactions. Bacteriophage cocktails, which scientists have started utilizing, enable more targeted treatment while also combating the formation of resistance.
Published Date: 2025-01-25; Received Date: 2023-09-27