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Occurrence of Protein S Deficiency - Related Multisystem Thromboembolism in a Patient with Myelodysplastic Syndrome after Allogeneic Hematopoietic Stem cell Transplantation | Abstract
Journal of Hematology & Thromboembolic Diseases

Journal of Hematology & Thromboembolic Diseases
Open Access

ISSN: 2329-8790

+44 20 3868 9735

Abstract

Occurrence of Protein S Deficiency - Related Multisystem Thromboembolism in a Patient with Myelodysplastic Syndrome after Allogeneic Hematopoietic Stem cell Transplantation

Anna Marie D. Espaldon*, Yi-Feng Wu, Wei-Han Huang, Sung-Chao Chu, Tso-Fu Wang, Chi-Cheng Li.

Introduction: Haemostatic derangements in the post-transplant period are characterized by decreased levels of factor VII, factor X, protein C, antithrombin III, and plasminogen and increased levels of fibrinogen, von Willebrand factor, plasminogen activator inhibitor, and tissue plasminogen activator, predisposing recipients to both thrombotic and haemorrhagic complications. No changes in protein S level were seen. However, a prospective study by Abdelkefi, showed a 1.7% prevalence of asymptomatic protein S deficiency in the post-transplant setting. to date, no report of protein S deficiency ??? related complications post-transplant was published. Herein we present a patient with myelodysplastic syndrome who underwent hematopoietic stem cell transplant (HSCT) complicated by an array of complications brought about by protein S deficiency.

Published Date: 2020-08-01; Received Date: 2020-07-12