Journal of Pharmacological Reports
Open Access
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+44-20-4587-4809
The meridian is a fundamental theory of Chinese Medicine. Based on this concept, Chinese Medicine physicians diagnose illnesses through analyzing the pulse of patients, and thereafter prescribe herbal formulae for remedy. During the past three decades, our research team found the meridian could be measured through pulse diagnosis. Meridians match to the harmonics of blood pressure pulse wave. With meridian theory, we discovered a series of compounds from Cnidii Fructus (Cnidium) which is a simplest herb formulae described in Shang Han Za Bing Lun. Including BMX, these compounds have being identified as HDAC8 inhibitor. Guided by the meridian effect on liver and gallbladder which dominate the blood perfusion of brain recorded in Chinese Medicine classic literature, BMX passes through BBB (blood brain barrier) in our study as expected. These results provide confidence to us for brain cancer therapy.