Antimicrobial resistance is one of the major leading problem and an issue for medical science in this era. Despite of being successful in treating bacterial infections and developing novel antibiotics, we are unfortunately going back to pre-antibiotic era. ESBLs, Cabapenemases and MCR-1 genes are the predisposing factors together in emerging the resistance. Horizontal gene transfer makes it favorable to spread resistance mechanisms at much faster rate. Antimicrobial resistance is taken as a more significant issue, when it comes towards the resistance of bacterial strains towards our lost-resort antibiotic i.E. colistin. Polymyxin E or colistin is an effective therapy against multidrug resistant pathogens i.e. ESKAPE. But, the discovery of MCR-1 gene has led to medical science to hands off at present. This mini-review aims to give a glance on MCR-1 gene mechanism of resistance in Escherichia coli and also plasmid profile and phenotypic characteristics of wildlife strains in continents, conferring resistance to colistin. As the global transmission of resistance has accounted the wild life as one of the major culprit.