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Traumatic brain injury (TBI) is a significant source of concern in the pediatric population. It has been estimated that close to 500,000-700,000 pediatric TBI incidents occur within the United States alone, with majority occurring in early childhood (<4 years) and early adulthood (>15 years). The management of TBI depends on its severity. It is the prevention of worsening of the secondary injury that is often targeted during the medical management. Given that TBI poses such a huge health risk, further understanding is required for adequate management of pediatric patients with TBI; especially due to the fact that their brain is still developing and has not completely matured.