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Langerhans Cell Histiocytosis Presenting with Central Diabetes Insipidus in an Adult: A Case Report with a Discussion on Differential Diagnosis, Diagnostic Work up and Treatment | Abstract
Internal Medicine: Open Access

Internal Medicine: Open Access
Open Access

ISSN: 2165-8048

Abstract

Langerhans Cell Histiocytosis Presenting with Central Diabetes Insipidus in an Adult: A Case Report with a Discussion on Differential Diagnosis, Diagnostic Work up and Treatment

Najeeb Shah*, Harshal Deshmukh, Shiva Mongolu, Muhammad Jawaid Akbar, Shah Rukh Malik, Shahbaz Nazir and Somil Rastogi

Langerhans Cell Histiocytosis (LCH) is rare in adults; the condition affects 1-2 patients per million annually in the general population. Diabetes Insipidus (DI) is a common manifestation of Langerhans Cell Histiocytosis (LCH) although its reported frequency varies in different series. The pathogenesis of the condition is not precisely understood. Infiltration of the hypothalamic-pituitary axis by Langerhans-like cells has been reported in 50% of autopsied patients. Central Diabetes Insipidus (CDI) can be familial, idiopathic or secondary and is a disorder characterised by polyuria, polydipsia and formation of hypotonic urine.

Published Date: 2021-03-12; Received Date: 2021-02-19