Applied Microbiology: Open Access
Open Access

Abstract

Incidence of Pseudomonas aeruginosa Resistance in Clinical Isolates from Selected Hospitals in Oyo State, Nigeria

Ajibade Oluwatosin1*, Oladipo EK1, 2, Aina KT1, Olotu TM1, Adeosun IJ1

Fifty clinical isolates of Pseudomonas aeruginosa were obtained from both in and out-patients of selected hospitals in
Oyo State, Nigeria using standard procedure. Presumptive identification of the isolates was carried out using
standard biochemical tests. according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. The
antibiotics used in the study includes: Ciprotab, Colistin-sulphate, Meropenem, Ceftriaxone and Cefepime. 50
clinical isolates of Pseudomonas aeruginosa obtained, consisting of 48% male isolates and 52%female isolates. The
percentage ratio of in-patient and out-patient examined were 32% and 68%. The percentage distribution of the
administration class for medical and surgical was 34% and 66% respectively. The highest incidence of
Pseudomonas aeruginosa was from patients that have undergone caesarean section (28%). Highest susceptibility was
observed in Ciprotab (82%) Meropenem (64%) and Ceftraxone (46%). Highest number of resistance was
observed against Cefepime and Colistin Sulphate while less than 5% were resistant to Ciprotab and Meropenem.
Meropenemand ciprotab were the two classes of drugs that showed highest activity against Pseudomonas
aeruginosa. Commonly used antibiotics must be continuously examined for its efficacy. There is therefore a need
for consistent screening of microorganisms implicated with various infections characterization of their antimicrobial
susceptibility pattern which will serve as a guide to clinicians in the selection of appropriate antimicrobial drug for
empirical treatment of infections.

Published Date: 2019-10-22; Received Date: 2019-09-30