Tong Woei Yenn, Syarifah Ab Rashid, Nurhaida, Latiffah Zakaria, Darah Ibrahim
This study was aimed to study the in vivo anti-MRSA of Penicillium minioluteum ED24, an endophytic fungus residing in medicinal herb Orthosiphon stamineus Benth by using rat models. No animal death or local reaction was observed in connection to the application of the test substance during the experimental period. The diameter of wound was concentration-dependent. The higher concentration of the fraction Ma10 used, the smaller wound was observed, where the diameter of wound observed for 2% fraction Ma10 was smaller than 1% fraction Ma10. At the end of the experiment, the lesions on animal models treated with 2% of fraction Ma10 was covered by epithelial tissue and the hair started to grow from the skin. The viable cells obtained from the skin sample were reduced with the increase concentration of fraction Ma10. Besides, the skin sample treated with Ma10 also showed the presence of hair follicles and sebaceous glands relative to the control based on the histological study.