Neurocysticercosis (NCC) is caused by the larva of Taenia solium, when it is lodged in the central nervous system (CNS). NCC is identified as the major cause of community acquired epilepsy, especially in the developing countries. It is also increasingly being reported in the developed world due to human migration from the disease endemic countries. However, some individuals with similar NCC lesions may remain asymptomatic and the reason for this asymptomatic status largely remains unknown. However, studies from our center suggest that cytokines play important role in disease pathogenesis. In the present review, we have discussed the role of different cytokines in the pathogenesis of NCC in human.