Journal of Tumor Research
Open Access

Abstract

How much Damage can make the Glucose in Cancer?

Montero S, Durán I, Pomuceno JP, Martín RR, Mesa MD, Mansilla R, Cocho G and Nieto-Villar JM

Using the entropy production rate method to determine the influence of glucose on a glycolysis model for HeLa tumor line, the greater complexity and robustness hypoglycemic phenotype was established. On the other side, inside the same metabolic phenotype a higher glucose concentration corresponds to a higher entropy production rate. It is concluded that this behavior is indicative of the directional character and stability of the dynamical behavior of cancer glycolysis.