Journal of Drug Metabolism & Toxicology
Open Access

Abstract

Hepatic Metabolism: The Liver?s Role in Drug and Toxin Processing

Dana Martin*

The liver plays a central role in the metabolism of drugs and toxins, acting as the body’s primary detoxifying organ. Hepatic metabolism involves a series of biochemical processes that convert lipophilic (fat-soluble) substances into more hydrophilic (water-soluble) forms, facilitating their elimination through urine or bile. This function is crucial not only for the clearance of drugs and foreign chemicals (xenobiotics) but also for determining their pharmacokinetics, therapeutic activity, and potential toxicity.

Published Date: 2025-03-04; Received Date: 2025-02-03