Adequate fluid resuscitation, pain control and organ support represent the cornerstones of treatment for acute pancreatitis. In this review, following questions will be answered on the basis of recent literature data: 1.What is the adequate volume of fluid to be administered and when should it be administered? 2. What type of fluid should be utilized? 3. What are the contraindications of an excessive amount of fluid? The suggestion to the practicing physician is that the amount of fluid administered patients with acute pancreatitis should be in the range of 3.1-4.1 l during the initial 24 hours after admission. The fluids used should be the lactated Ringer’s solution because the pH is more balanced than simple saline solution. Caution should be recommended regarding early fluid administration; the fluid should be administered under continuous monitoring.