Journal of Molecular Imaging & Dynamics
Open Access

Abstract

Fibrinolytic Enzyme: Restoration Tool for Obliteration of Blood Clots

Hajra Ashraf, Bisma Meer, Romasa Naz, Aarooj Saeed and Pervez Anwar

Body interrelated complex system maintain body hemostasis but severe vascular injury reprehensible for thrombus formation. Fibrinogen is a prime protein in fibrinolysis. Complex cascade pathway involves in conversion of plasminogen to plasmin to perform fibrinolysis and plasminogen activating inhibitor (PAI) cease this pathway. The genetic and acquired factors influence clot formation while it curbs by factor VIII. This review aims to illustrate significance of fibrinolytic enzymes, Nattokinase, Urokinase, Staphylokinase and streptokinase as therapeutic agent to control myocardial infraction, venous stroke and pulmonary clotting.