Pancreatic Disorders & Therapy

Pancreatic Disorders & Therapy
Open Access

ISSN: 2165-7092

+44 1478 350008


Feasibility of Mesenteric Vein Reconstruction with PTFE Prosthesis for Non Functioning Endocrine Pancreatic Tumor Surgery

Fratini Geri, Giudici Francesco, Bellucci Francesco, Batignani Giacomo and Tonelli Francesco

Endocrine pancreatic tumors (EPTs) are rare entities with a low incidence (3-10 per million). A relatively frequent feature (15-53%) among this group of tumors is represented by the non-functioning endocrine pancreatic tumors (NFEPTs) whose peculiarity is due to the absent secrection of mature or active hormones, leaving the patient free from clinically evident hypersecrection syndromes, generally discovered when the mass effect becomes evident, the adjacent pancreatic structures (splenic, superior mesenteric and portal vein, celiac or superior mesenteric arteries, common bile duct, duodenum, etc.) are infiltrated or hepatic metastases are growing. A potentially malignant attitude is high and well related to the dimension of the tumor with inexorably fatal outcome if appropriate surgery is delayed. The size of the mass and an evident involvement of nearer vascular structures might rise some doubts about the decision to radically remove the tumor. An aggressive surgery should be balanced with the risk/benefit ratio for generally young patients with a reasonable long life expectancy. We parallel two clinical cases among the patients we observed through the years at our institution and operated on by the same surgeon, who were displaying the same tumoral histology and loco-regional invasiveness of portomesenteric axis, but differing one each other for the presence of metastatic disease to the liver the first case. Further aim of the present report is to support the evidence of the feasibility and safeness of extensive surgical demolition with prosthetic reconstruction of the porto-mesenteric axis.