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In this semi-experimental study, general knowledge of 60 high school students about different kinds of drugs was assessed by a 60-question test. Four 45-minute training session was held for the effects, side effects and treatment methods of drugs. Their general knowledge was re-evaluated at the end of this course. Data analyzed with t-test. The accurate general knowledge of the groups about drugs did not exceed 50%. No significant difference was observed between the experimental female and male groups. Through a short-time training course, the level of the false knowledge of the students can be decreased and the level of their accurate knowledge can be increased.