Endorphins are endogenous morphine, neuropeptide, produced from pituitary gland in response to stress and pain. There are three types of endorphins are beta-endorphins, dynorphins, enkephalins binds to mu, kappa, and delta receptors found on immune cells and nervous system. Beta-endorphins is a most abundant endorphins synthesized and stored in the anterior pituitary gland. It has got various activities such as immune stimulatory, antiinflammatory, analgesic activity, delay aging, stress buster activity involved in preventive, promotive, therapeutic and palliative treatment of various diseases such as cancer, auto-immune diseases, infectious disease without any adverse effects. This article briefs about the novel roles of endorphins especially beta-endorphins and its action in holistic treatment of diseases.