Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
ISSN: 2161-1017
Rutong Wang*, Yanhong Wei, Mengyao Wang, Liujun Huang, Yujia Guo, Nong Weihua, Xiaocan Lei
The meta-analysis of inositol for the prevention of Gestational Diabetes Mellitus (GDM) is still a subject of debate due to issues such as small sample sizes and racial disparities. The aim of this comprehensive meta-analysis is to derive an overall effect and provide a succinct and definitive conclusion. The search was conducted up to July 2024 in international scientific databases, including PubMed, Web of Science and Embase. All meta-analyses investigating the role of inositol in preventing GDM were included in this study. Depending on the heterogeneity, both fixed and random effects models were employed to obtain pooled results. The I2 statistic and Cochrane Q test were utilized to assess the heterogeneity among studies. The quality of the included meta-analyses was evaluated using the Assessment of Multiple Systematic Reviews 2 (AMSTAR2) checklist. A total of 12 studies were included, encompassing 9,018 patients. The results indicate that inositol supplementation significantly reduced the incidence of GDM (RR: 0.37; 95% CI: 0.32, 0.42). For secondary outcomes, inositol supplementation notably decreased Fasting Plasma Glucose levels (FPG) (SMD: -1.31; 95% CI: -1.83, -0.79) and improved the one-hour Oral Glucose Tolerance Test (1 h OGTT) (SMD: -2.63; 95% CI: -3.87, -1.40) and the two-hour Oral Glucose Tolerance Test (2 h OGTT) (SMD: -0.95; 95% CI: -1.56, -0.34). The supplement also significantly reduced the risk of preterm birth (RR: 0.37; 95% CI: 0.28, 0.47) and Pregnancy-Induced Hypertension (PIH) (RR: 0.34; 95% CI: 0.25, 0.47). Notably, inositol had a significant effect on reducing the rate of cesarean section (RR: 0.82; 95% CI: 0.71, 0.94). However, the impact on the incidence of macrosomia was not statistically significant (RR: 0.70; 95% CI: 0.33, 1.49). The meta-analysis also found that birth weight (SMD: -0.25; 95% CI: -0.32, -0.17) and the incidence of neonatal hypoglycemia were significantly reduced (RR: 0.30; 95% CI: 0.08, 1.21). Inositol supplementation had no significant effect on gestational age at birth (SMD: -0.13; 95% CI: -0.04, 0.29). The findings of this study support the effectiveness of inositol supplementation in the prevention of GDM.
Published Date: 2025-01-10; Received Date: 2024-08-09