Journal of Drug Metabolism & Toxicology
Open Access

Abstract

Effect of Manasamitra Vatakam Against Aluminium Induced Learning and Memory Impairment of Apoptosis in Rat ’ s Hippocampus and Cortex

Thirunavukkarasu SV, Jayanthi M, Raja S and Venkataraman S

The present study investigates

neuronal cell

death and neuroprotective effect of Manasamitra vatakam ( MMV ) against Aluminum (Al)-induced toxicity in rats. Aluminum and its salts extensively damaged nervous system and impaired learning and memory animals in neurodegenerative disease. In this study were conducted five groups, six animals in each group. In these study reveals Al caused neuronal apoptosis and cognitive dysfunction of animals brain regions (Hippocampus and Cortex) that could be restrain by treated with Manasamitra vatakam. MMV is a herbo-mineral formulation and prepared on the basis of Indian system of

Ayurvedic medicine

. These formulations using psychiatric treatment in Indian scenario, obviously tried for alternative treatment against Aluminium induced cognitive dysfunctions. It causes synthesis, release of neurotransmitter 5-hydroxytryptamine (5-HT), antioxidants, inhibit apoptotic genes and improve

cognitive functions

of animals. Apoptotic, anti-apoptotic genes such as Bcl-2, Bcl-xL and caspas-3 were estimated by Western blot and Reverse transcriptase polymerase chain reaction (RT- PCR). In these results clearly observed that MMV treatment was markedly increased 5-HT and restrain cognitive functions as well as decreased expression of pro-apoptotic genes against Al induced animals . This result indicates MMV could activate learning and memory function of animals due to inhibition of apoptotic genes like Bcl-2, Bcl-xL and caspas-3 . The present study reveals that Ayurvedic formulation of Manasamitra vatakam ( MMV) as potentially inhibited neuronal apoptosis and enhanced

cognitive function

leads to learning memory function against Al induced neuodegenerative disease.