Anesthesia & Clinical Research
Open Access

Abstract

Effect of lidocaine Instillation into Endotracheal Tube on Intraocular Pressure during Extubation

Ahmed Hassanein, Josef Zekrly and Hosam Moharram

Objectives: To study the effect of lidocaine instillation into endotracheal tube before extubation on intraocular pressure (IOP) and hemodynamics.

Patients and methods: 60 patients, (ASA) I-II, ages between 18 to 40 years were scheduled for elective unilateral ocular surgery (cataract, squint and ptosis). Patients were randomly classified into two groups of 30 patients each: lidocaine group; received 1 mg/kg lidocaine into the endotracheal tube before extubation, and control group; received saline into the endotracheal tube. IOP, systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were all measured before and after extubation.

Results: a significant increase of IOP in control group at 2, 5 and 10 minutes after extubation (P<0.01) when compared to baseline value (2 min. before extubation). The elevation in IOP in lidocaine group at 2 min was significantly less than that in control group (P<0.05), the readings of IOP at 5 and 10 min. was lower in lignocaine group compared to control group. Both groups showed significant increase in SBP and DBP after extubation compared to baseline (2 min. before extubation), and elevation in lignocaine group was significantly lower than that of control group (p=0.0001).

Conclusion: Instillation of lidocaine into endotracheal tube before extubation attenuates IOP after extubation