International Journal of Physical Medicine & Rehabilitation
Open Access
ISSN: 2329-9096
+44 1300 500008
ISSN: 2329-9096
+44 1300 500008
Naglaa A Hussein and Gihan M Sharara
Objective: To compare the effect of comprehensive rehabilitation program versus combined garlic therapy and comprehensive rehabilitation program in controlling the clinical manifestations and quality of life in patients with knee osteoarthritis
Design: Randomized clinical trial
Setting: Outpatient setting
Participants: 43 patients with knee osteoarthritis randomized to group I (comprehensive rehabilitation) (n=15) and group II (combined garlic therapy and comprehensive rehabilitation) (n=28).
Intervention: All patients had diet modification, electrotherapy, resistance and flexibility exercises for legs 3 times weekly for 8 weeks. Group II received garlic capsules 900mg daily with breakfast for 8 weeks.
Main Outcome measures: knee pain by visual analogue scale (VAS), Stanford health assessment questionnaire (HAQ), one repetition maximum (1RM) for quadriceps, body mass index (BMI), synovial fluid level of interleukin1β, interleukin 6, tumor necrosis factor ά and selenium.
Results: BMI significantly decreased in both groups (Ρ‹.05) without significant difference between groups. Knee pain significantly decreased in group II mean ± standard deviation (-51.77 ± 11.17%) more than in group I (-22.92 ± 5.31%) (Ρ=.00001). 1 RM significantly increased in group II (105.10± 65.90%) more than in group I (64.78 ± 54.77%) (Ρ=.01986). Percent change of HAQ was more in group II (-36.56 ± 12.2) than in group I (-16.42 ± 14.10) (Ρ=.00004). Synovial selenium significantly increased only in group II (213.19 ± 28.26%) (Ρ=.00001). Synovial inflammatory mediators significantly reduced only in group II (interleukin1β (-89.67% ± 3.73) (Ρ=.00001), interleukin 6 (-92.98% ± 5.02) (Ρ=.00001), tumor necrosis factor ά (-83.20% ± 8.52) (Ρ=.00001).
Conclusion: Garlic improves rehabilitation outcome of knee osteoarthritis