Journal of Fertilization: In Vitro - IVF-Worldwide, Reproductive Medicine, Genetics & Stem Cell Biol
Open Access

Abstract

Correlation of Serum Nesfatin-1 Level with Metabolic and Clinical Parameters in Indian Women with and without Polycystic Ovarian Syndrome

Feiza Fatima*, Saxena Pikee and Jain Anju

Objective: To compare serum nesfatin-1 levels in Indian women with and without Polycystic Ovarian Syndrome (PCOS) and to evaluate the association of serum nesfatin-1 with metabolic and clinical parameters. Materials and methods: 40 PCOS and 40 age and Body Mass Index (BMI) matched non PCOS controls were enrolled. Comparison of hormonal (serum nesfatin-1, Anti-Mullerian Hormone (AMH), Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), prolactin, testosterone, estradiol) metabolic (blood pressure, fasting and post prandial blood glucose and insulin, Homeostasis Model Assessment-estimated Insulin Resistance (HOMA-IR) and clinical (acne, acanthosis nigricans and hirsutism) parameters was done between two groups. Student’s t test, Mann Whitney test, Pearson’s correlation test were used. Here p value of <0.05 was considered statistically significant. Results: There was a significant difference in levels of serum nesfatin-1 in PCOS subjects and controls (8.6 ng/ml vs. 0.75 ng/ml, p<0.01). Positive correlation was present between serum nesfatin-1 levels and post prandial plasma glucose (r=0.009; p<0.009). A positive correlation was also present between serum nesfatin-1 levels and AMH (r=0.512; p<0.01). No correlation was found between serum nesfatin-1 and other endocrine, cardiovascular and metabolic parameters. Serum LH levels, LH/FSH ratio, post prandial plasma glucose and post prandial insulin were significantly higher (p<0.05) in PCOS subjects compared to controls. Conclusion: Nesfatin-1 levels were ten times higher in PCOS subjects compared to controls irrespective of age and BMI. A positive correlation was observed between serum nesfatin-1 and post prandial plasma glucose levels which indicates nesfatin-1 may be a reliable marker of PCOS suggesting energy homeostasis imbalance in these women.

Published Date: 2022-12-23; Received Date: 2022-11-10