Journal of Applied Pharmacy
Open Access

Abstract

CONCENTRATION AND TIME DEPENDENT EFFECT OF ALUMINIUM METAL ON GLUTATHIONE LEVEL IN PLASMA OF HUMAN BLOOD

Haroon Khan, Muhammad Farid Khan, Syed Umer Jan, Kamran Ahmad Khan, Kifayat Ullah Shah And Ameer Badshah

Aluminium is an important metalloelement and has many medicinal uses like use of aluminum as an antacid. Thus it is interesting to study the effect of Aluminium on the glutathione (GSH) in vivo conditions. The concentration and time dependent effect of Aluminium on glutathione level in plasma was studied by using Ellman’s method. A drastic effect on decreasing the concentration of glutathione level in plasma was found by increasing the concentration of Aluminium sulphate over the time. The reason could probably be due to oxidation of GSH to corresponding disulphide (GSSG). In this paper the effect of Aluminium metal on thiol/GSH level was discussed in vitro, which in principal may present a model of in vivo reaction