Journal of Applied Pharmacy
Open Access

Abstract

COMPARATIVE ANTILIPIDEMIC EFFECTS OF NATIVE AND GEMMOTREATED WITHANIA SOMNIFERA (ASGHAND) EXTRACTS

Fouzia Khursheed, Khalil-ur-Rehman, Muhammad Shoaib Akhtar, M. Zahoor-ul-Hassan Dogar, Bilal Khalil

Antilipidemic activity was measured by estimating the levels of lipidemic markers such as total, HDL & LDL cholesterol, and triglycerides, before and after treatment with Gemmo and extracts from native plants. It was observed that antilipidemic activity were more efficient in Gemmo treated groups as compared to natively treated animals. Moreover, Gemmo extracts exerted significant antilipidemic effect in isoproterenolinduced myocardial infarction by maintaining the level of total, HDL & LDL cholesterols and triglycerides. Antilipidemic activity of Withania somnifera might be due to alkaloids and special compounds called Withanolides. It is conceivable that that these plant constituents are probably more active in form of Gemmo-extracts than in the native form.