Psoriasis is an autoimmune, non-infectious, inflammatory disorder of the skin with the hyper proliferation of the skin. Psoriasis can be considered as the vitiation of Vata and Kapha. The characteristics of Ek Kustha resemble with the Generalized Psoriasis Vulgaris. Ayurveda advocates various palliative and purificatory therapies for the management of psoriasis. Neem used by Charak in Kustha Chikitsa as Churna, Paan, Lepa, Tail. Sushrut advised neem in Kustha as Churna, Kwath, Lepa and Snana. Tulsi used by Charak in Kustha as Lepa, Nashya, Kshir and Tail. Heena is the important ingredient of Mahaneela ghrita used by Sushruta in Kustha Chikitsa. Therefore, a study was planned with the aim to assess the efficacy of Neem, Tulsi and Heena in the treatment of psoriasis. Out of 30 patients in group A, 53.3% patient showed cured, 33.3% showed improved and 13.3% showed mild improved. In group B, 80% patient showed cured, 13.3% improved and 6.6% mildly improved. Findings of both the groups suggest that selected drugs are effective, but better results were observed in Group B where both the drugs were administered to the patients.