Entomology, Ornithology & Herpetology: Current Research
Open Access

Abstract

Cholesterol Uptake Targeted Growth Regulation to Control Disease Transmitting Vector Populations

Sarvananda Letchuman* and Amal D Premarathna

Cholesterol is one of the vital compounds required maintain principal metabolic pathways and structural material in the human and animal body. Insects are lack of the essential enzymes required for the biosynthesis of cholesterol from precursor molecules in nature and which makes them depend on dietary cholesterol. Thus the blocking of cholesterol uptake interfere the metabolic pathways of insects and effects on the survival of the them. Based on this characteristic nature, certain phytochemicals can be applied to inhibit Aegypti Sterol Carrier Protein 2 (AeSCP-2) activity via competitive binding and proven to have effective insecticidal activities against disease transmitting mosquitoes and other insect vectors. Range of candidate compounds and plant sources, that block the cholesterol uptake in insects, can effectively be used to prevent and spread of vector born disease have been discussed.

Published Date: 2021-09-27; Received Date: 2021-09-06