Caffeine is widely consumed by the world population due is a major constituent of beverages like as coffee and tea. Additionally, caffeine supplementation is also taken by many athletes due its ergogenic properties. Thus, several studies demonstrated that caffeine supplementation have significant antioxidant and anti-inflammatory activity. Our study evaluated the caffeine intake associated with swimming exercise in rats. We found that caffeine and exercise training did not change the mitochondrial parameters as compared with control group. However, our results demonstrated that caffeine intake are highly efficacious in modulate inflammation biomarkers.