Jianqin Wu and Limin Chen
Human parvovirus B19 (B19) belongs to the family of parvoviridae and viral particle measures 23 nm in diameter. B19 virus has single-stranded DNA genome and is n non-enveloped virus. It is widespread in the world. The virus can be transmitted via respiratory route and blood-derived products in addition to be transmitted vertically from mother to fetus. B19 infection can cause a lot of symptoms, such as fever, headache, erythema infectiosum, ystemic lupus erythematosus, hydrops fetalis. Because B19 virus is resistant to heat inactivation and solvent detergents, the risk of B19 virus transmission through transfusion still exists.