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Autoimmune hemolytic anemia (AIHA) is the most common extracorpuscular hemolytic anemia. AIHAs are related to the presence of autoantibodies directed against components of the erythrocyte membrane. To date, data related to AIHA are rare, primarily from retrospective studies of small effective. To our knowledge, data related to AIHA in elderly subjects are almost non-existent. Thus, we report our experience of 10 consecutive patients older than 75 years with a documented AIHA.