Rapid industrialization, deteriorating the quality of water leads towards disastrous health effects among the inhabitants of the areas with numerous industries. This study is a brief reflection of the toxicological effects of industrialization on water resources, as well as the pharmacological effects of contaminated household and drinking water on animal model of an industrialized area in a developing country. The obtained results of this study showed high concentration of some heavy metals in the water used in industrial area, than the maximum permissible limit that can be present in water according to the WHO guidelines of water which might cause anomaly in blood composition, severe effect on vital organs such as kidneys and livers. Successively, significant abnormalities were observed in the organs of the tested rat models drinking the water. Therefore, the findings of this study can be used to implement the long term study by broadening the sampling areas and to further elucidate the molecular mechanisms and public health impact associated with human exposure to water contaminated in the industrial areas.