Muthukumaran Pakkirisamy*, Nicholas Daniel, Jayaraj Mani
This present study was to investigate the invitro antioxidant and anti-inflammatory activity of aqueous extract of Nilavembu kudineer choornam (NKC).Phytochemical screening that used in the present study was a conventional method. The antioxidant activity was evaluated by various antioxidant assays, including DPPH, Nitric oxide (NO) Hydrogen peroxide (H2O2) scavenging and Reducing Power method. The antioxidant activities were compared to an antioxidant Ascorbic acid. The Nilavembu kudineer choornam (NKC) were extracted using water solvent into different concentration (50 mg/mLto 250 mg/mL). Diclofenac sodium was used as the standard. Anti-inflammatory assays were performed by the human red blood cell (HRBC) membrane stabilization method, Antiproteinase activity and Anti-lipoxygenase activity. Phytochemical screening showed the presence of Alkaloids,Flavonoids ,Tannins,Steroids ,Glycosides,Triterpenoids ,Saponins and Phenol . Nilavembu kudineer choornam (NKC) showed a significant antioxidant and anti-inflammatory activity. The highest protection capability possessed by the extract of Nilavembu kudineer choornam (NKC) in human red blood cell (HRBC) membrane stabilization method , Antiproteinase activity and Anti-lipoxygenase activity was at a concentration of 250 mg/mL. The findings of the present study suggested that Nilavembu kudineer choornam (NKC) could be a potential natural source of antioxidants , anti-inflammatory activities by in vitro assays and could have greater importance as therapeutic agent in preventing or slowing oxidative stress related degenerative diseases.
Published Date: 2021-10-22;