Abnormal hair development and regeneration occurs in some skin diseases, including lymphomas when hair follicles are eliminated. Otherwise, neoplastic cells, both malignant and benign, local occurring and metastatic, can cause alopecia of the scalp. In lymphomas alopecia can develop due to direct infiltration by the disease, or it may be a secondary or paraneoplastic manifestation. Total -body hair loss can be diagnosed only in those with generalized erythroderma in mycosis fungoides and Sézary syndrome. Patchy alopecia clinically identical to alopecia areata is revealed in 34% patients suffering from mycosis fungoides or Sézary syndrome. Discreet patch/plaque or follicular lesions is observed within mycosis fungoides lesions in 66%. The involvement of hair follicles usually presents in folliculotropic mycosis fungoides. 65% of patients have alopecia. Follicular mucinosis is frequent in folliculotropic mycosis fungoides. Alopecia is also observed in ichthyosiform mycosis fungoides, syringotropic cutaneous T-cell lymphoma panniculitis-like T-cell lymphoma, primary cutaneous follicle center lymphoma Occipital alopecia areata, occipital and parietal alopecia were observed in B- cell lymphoma. Alopecia is a rare manifestation of Hodgkin’s disease. Alopecia may develop due to therapy and can be even a sign of therapeutical efficacy.