Knowledge of vascular variations, especially arterial variations, is very important for surgeons, radiologists and to certain extent to the other clinicians. Awareness of the possible variations will reduce the risk of complications like bleeding during surgical procedures. Occasionally these anatomical variations of arteries may result in erroneous interpretation of angiograms by radiologists. Sometimes these variations may become advantageous for the plastic surgeons in preparation of pedicle grafts. Hence we report a rare variation of high origin of superficial brachial artery from the second part of axillary artery. Superficial brachial artery continued as the main brachial artery in the arm, and terminated as radial and ulnar arteries in the cubital fossa. However the radial artery was much narrower in diameter.