Journal of Medical & Surgical Pathology
Open Access
ISSN: 2472-4971
ISSN: 2472-4971
Imane Eliahiai*, Mohammed Eljiar, Sanae Chaib, Khalid Mourabit, Jinane K Harmoum, Mariame Chraibi
Breast cancer remains the most deadly cancer in women worldwide. It is a highly heterogeneous disease group, both biologically and molecularly. Mammary carcinogenesis is a multi-stage, complex and progressive process, involving the accumulation of several genetic and epigenetic abnormalities of interest to oncogenes and suppressor genes. Understanding the molecular pathogenesis of breast cancer helps to explain early and aggressive forms of the disease, to understand the mechanisms of therapeutic resistance and to search for new prognostic or theranostic markers. We reviewed 38 synthesis and review articles published between 2008 and 2022, dealing with breast carcinogenesis or focusing on a specific molecular pathway. Among them, we selected 29 articles to summarize the main molecular abnormalities involved in breast carcinogenesis, with particular emphasis on molecules considered in the literature as prognostic or theranostic markers.
Published Date: 2025-03-18; Received Date: 2024-04-15