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The immune system of an organism protects against disease by identifying and killing pathogens and tumor cells. But sometimes it may over-react or start attacking the body and results in immune-mediated diseases. Autoimmune diseases like allergic diseases, Sinusitis, atopic dermatitis, allergic asthma, idiopathic dilated cardiomyopathy, rheumatoid arthritis and some HIV associated diseases are part of immune mediated diseases. In this review we highlight some of the immune mediated diseases along with their diagnostic methods and therapeutic approaches.