ISSN: 2169-0111
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Mitochondria play a central role in cellular energy provision. The organelles contain their own genome with a modified genetic code. The mammalian mitochondrial genome is transmitted exclusively through the female germ line. The human mitochondrial DNA (mtDNA) is a double-stranded, circular molecule of 16 569 bp and contains 37 genes coding for two rRNAs, 22 tRNAs and 13 polypeptides. The mtDNA-encoded polypeptides are all subunits of enzyme complexes of the oxidative phosphorylation system. Mitochondria are not self-supporting entities but rely heavily for their functions on imported nuclear gene products. The basic mechanisms of mitochondrial gene expression have been solved. Cis-acting mtDNA sequences have been characterised by sequence comparisons, mapping studies and mutation analysis both in vitro and in patients harbouring mtDNA mutations.
Short Communication: Advancements in Genetic Engineering
Clinical image: Advancements in Genetic Engineering
Opinion Article: Advancements in Genetic Engineering
Short Communication: Advancements in Genetic Engineering
Editorial: Advancements in Genetic Engineering
Keynote: Journal of Cell Science & Therapy
Scientific Tracks Abstracts: Journal of Cell Science & Therapy