Journal of Cancer Research and Immuno-Oncology
Open Access

Cancer Glycobiology

Cancer cells depend on altered metabolism and nutrient uptake to generate and keep the malignant phenotype. The hexosamine pathway is a branch of glucose metabolism that produces UDP-GlcNAc and others donor substrates used in the production of glycoproteins, glycosaminoglycans and glycolipids. Thus, metabolite availability to the hexosamine pathway exerts control over the biosynthesis of glycoconjugates, signaling and gene expression. An imbalance in the glycoconjugate biosynthesis can, therefore, produce profound alterations in cell function. Indeed, aberrant glycosylation on cell surface mediate key