Variation in Mu-Opioid Receptor Gene (OPRM1) as a Moderator of Naltrexone Treatment to Reduce Heavy Drinking in a High Functioning Cohort

Andrew CH Chen^1,2*, Jon Morgenstern¹, Christine M Davis², Alexis N Kuerbis², Jonathan Covault³ and Henry R Kranzler⁴

¹Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, USA

²Research Foundation for Mental Hygiene, Inc., New York State Psychiatric Institute, New York, USA

³Department of Psychiatry, University of Connecticut Health Center, Farmington, CT, USA

⁴Treatment Research Center, Department of Psychiatry, Perelman School of Medicine of the University of Pennsylvania and VISN4 MIRECC, Philadelphia VAMC, Philadelphia, USA

^*Corresponding Author: Andrew CH Chen, Department of Psychiatry, College of Physicians and Surgeons of the Columbia University, 1775 Broadway, Suite 1404, New York, USA, Fax: 212-974-0530 Email: